When a litter of dalmatian puppies are abducted by the minions of Cruella De Vil, the parents must find them before she uses them for a diabolical fashion statement. In a Disney animation classic, Dalmatian Pongo is tired of his bachelor-dog life. He spies lovely Perdita and maneuvers his master, Roger, into meeting Perdita's owner, Anita. The owners fall in love and marry, keeping Pongo and Perdita together too. After Perdita gives birth to a litter of 15 puppies, Anita's old school friend Cruella De Vil wants to buy them all. Roger declines her offer, so Cruella hires the criminal Badun brothers to steal them -- so she can have a fur coat.

Being one of 101 takes its toll on Patch, who doesn't feel unique. When he's accidentally left behind on moving day, he meets his idol, Thunderbolt, who enlists him on a publicity campaign.