In the year 180, the death of Emperor Marcus Aurelius throws the Roman Empire into chaos. Maximus is one of the Roman army's most capable and trusted generals, as well as a key advisor to the emperor. As Marcus' devious son Commodus ascends to the throne, Maximus is sentenced to execution. He escapes but is captured by slave traders. Renamed "Spaniard" and forced to become a gladiator, Maximus must battle to the death against other men for the amusement of paying audiences.

Years after witnessing the death of the revered hero Maximus at the hands of his uncle, Lucius is forced to enter the Colosseum after his home is conquered by the tyrannical Emperors who now lead Rome with an iron fist. With rage in his heart and the future of the Empire at stake, Lucius must look to his past to find strength and honor to return the glory of Rome to its people.