Since the sudden and suspicious deaths of his parents, young Damien has been in the charge of his wealthy aunt and uncle and enrolled in a military school. Widely feared to be the Antichrist, he relentlessly plots to seize control of his uncle's business empire — and the world.

Damien Thorn has helped rescue the world from a recession, appearing to be a benign corporate benefactor. When he then becomes U.S. Ambassador to the United Kingdom, Damien fulfills a terrifying biblical prophecy. He also faces his own potential demise as an astronomical event brings about the second coming of Christ.

Immediately after their miscarriage, the US diplomat Robert Thorn adopts the newborn Damien without the knowledge of his wife. Yet what he doesn’t know is that their new son is the son of the devil.

Damien Thorn is dead, but his prophecy is reborn in a mysterious girl named Delia, who is adopted by two attorneys.

When a young American woman is sent to Rome to begin a life of service to the church, she encounters a darkness that causes her to question her own faith and uncovers a terrifying conspiracy that hopes to bring about the birth of evil incarnate.