While escorting an elderly man to an undisclosed location, The Driver is confronted by a van full of armed men and is warned that the old man has stolen a large amount of diamonds. The old man claims to have swallowed the diamonds and that the men will likely cut him open to retrieve them. The Driver decides at the last minute to help him, participating in a car chase and shootout with the van. The Driver eventually evades his pursuers and watches their destruction. He then delivers the old man to a town nearby and asks the merchant if he did indeed swallowed the diamonds. The client merely chuckles and walks away. The Driver then leaves.

The Driver is carrying an Asian child who has been chosen for a strange ritual. He must drive him through a dark night in the city to get to a monk's house, while eluding several American cars out to get the child.

The Driver is hired by a nervous movie manager to spy on a paranoid actor's wife. During his tailing of the wife, the Driver describes the right way to tail someone. As he follows her he begins to fear what he might learn of her apparently tragic life. He discovers the wife is fleeing the country and returning to her mother's, and that she's been given a black eye, likely by her husband. He returns the money for the job, refusing to tell where the wife is, and drives off telling the manager never to call him again.

The Driver is drafted by the UN to rescue a wounded war photographer named Harvey Jacobs from out of hostile territory. While they are leaving Jacobs tells the Driver about the horrors he saw as a photographer, but he regrets his inability to help war victims. Jacobs answers the driver curiosity about why he is a photographer by saying how his mother taught him to see. He gives the Driver the film needed for a New York Times story and also his dog tags to give to his mother. When they reach the border, they are confronted by a guard who begins to draw arms as Jacobs begins taking pictures, trying to get himself killed. The Driver drives through a hail of gunfire to the border, but finds Jacobs killed by a bullet through the seat. The Driver arrives in America to visit Jacobs' mother and share the news of him winning the Pulitzer prize and hand over the dog tags, only to discover that she is blind.

The Driver now carries an arrogant rock star who is visiting a major city (not Pittsburgh as earlier believed). Played by Madonna, this title character wants to get away from her bodyguards in the Driver's BMW. He soon gets tired of her and decides to have a bit of fun.

The Driver drag-races the Devil, in order to earn James Brown his soul.

The Driver drives a wounded diplomat, who carries a mysterious briefcase, while under helicopter attack. During the attack the briefcase is struck by a bullet, causing a display on it to begin counting down, and it to leak an unknown fluid from the bullet hole. The Driver manages to destroy his pursuers, but refuses to proceed without knowing the contents of the damaged briefcase. It is revealed that the diplomat guards a human heart for a peacekeeper, whose life is needed for the continued freedom of the people. The case is delivered, and the tyrant is forced to give up his attempt to take the country by force. The Driver leaves for another mission.

The Driver is hired by the FBI to help defuse a hostage situation. A disgruntled employee has kidnapped a CEO and has hidden her, demanding $5,088,042. The Driver delivers the money, writing the sum on his hand as instructed by the hostage taker. After he is told that he holds the life of a person in his hand, he is ordered to burn the money. As he complies, the federal agents break in and attempt to subdue the man, who shoots himself in the head before he reveals where the woman is hidden. The Driver then tries to find the hostage before she drowns in the trunk of a sinking car. As a twist, the kidnapped woman is revealed to be the hostage taker's lover. She coldly taunts the dying man in the hospital.

After the controversial disappearance of their Chief Medical Officer, a shadowy bio genetics company is under siege by the FBI for secretly cloning humans. Amidst the chaos, Molgen’s head mercenary Holt is sneaking out the last living clone, a young woman named Lily to a mysterious buyer. Holt has hired The Driver, accompanied by a heavily armed squadron of fellow Molgen mercenaries, to evade the authorities and deliver Lily and himself to the buyer. The journey takes an unexpected turn and Holt is forced to take matters into his own hands, as the driver once again demonstrates his mettle and extraordinary driving skills.