Legend has it that the human race is not the only dominant civilization living on Earth. Two other races exist in this world: the Makai (a demon race) and the Jujinkai (a half-man, half-beast race). Once every 3,000 years, a supreme being known as the "Choujin" (Overfiend) will emerge and bring balance to all three realms on Earth. In present-day Japan, after 300 years of endless searching, a Jujinkai named Amano Jyaku has discovered the presence of the Choujin inside high school slacker Tatsuo Nagumo. But now, Amano, along with his sister Megumi and their sidekick Kuroko must protect Nagumo and his new girlfriend Akemi Ito from the Makai, who believe that Nagumo is not the Choujin, but an evil entity bent on destroying all living beings on Earth.

In this sequel to Urotsukidoji: Legend of the Overfiend, the unbelievable sexual violence of the Overfiend and his cohorts from Hell continues to wreak havoc on the earth. Who can stop this relentless onslaught? Urotsukidōji II: Legend of the Demon Womb was originally released as a 2 episode OVA series from December 1, 1990 to April 10, 1991 but was later re-release as a compilation film on July 21, 1991.

As the Overfiend slumbers, the mad emperor Caesar rises to power, enslaving a new race of demon beasts. Into this cruel existence is born the Lord of Chaos, the Overfiend's nemesis. As the blood-thirsty beasts capture the tyrant's daughter in a brutal coup, the Overfiend must awaken to an apocalyptic battle of the Gods.

It is the age of the Overfiend, and flesh-hungry monsters rule the Earth. Immortal half-demon Amano Jyaku travels the wasteland, witness to the rape and torture of the human race. The last hope for humanity is the demonic Lord of Chaos, the Overfiend's natural enemy. Will the world survive their final battle?

Only one episode of this was partially completed, the released version containing numerous examples of animation that is missing in-between frames. The story as such concerned the arrival of the real Chojin as he/she (a hermaphrodite) makes moves to wipe out all life on Earth. Interestingly, the setup for the show was far more heavily connected with the first two, more popular, chapters in the Urotsukidoji saga, with appearances by Nagumo and Akemi (unseen since the early episodes of Part III), and redesigned character models that more closely resembled the earlier episodes. Some of the less popular characters introduced in chapters III and IV, particularly Buju, were nowhere to be seen. Nevertheless, such strategies did little to get this final saga off the ground and the story was shelved.