The movie follows Joe, a heroin addict, throughout his quest to score more drugs. The episodic plot occurs over a single day and centers on Joe's problematic relationship with his on-off, sexually frustrated girlfriend. During the course of the day, Joe overdoses in front of an upper-class couple, attempts to fool Welfare into approving his methadone treatment by having Holly fake a pregnancy, and frustrates the women in his life with his drug-induced impotence.

A heroin junkie works as a prostitute to support his habit and fund an abortion needed by the girlfriend of his lesbian wife. His seedy encounters with delusional and damaged clients, and dates with drag queens and hustlers are heavy on sex, drugs and decadence.

Former child star Joe Davis, reduced to living in a cheap Hollywood motel while struggling for acting jobs, is lusted after by nearly every woman he meets, including Jessica Todd, a tightly wound feminist who has recently come out as a lesbian. When Jessica's mother, Sally, an emotionally needy has-been actress, meets Joe, she moves him into her enormous, tacky mansion as her new boy toy and attempts to get him acting work.