The first manned spacecraft, fired from an English launchpad, is first lost from radar, then roars back to Earth and crashes in a farmer's field, and is found to contain only one of the three men who took off in it; and he is unable to talk but appears to be undergoing a torturous physical and mental metamorphosis.

In England, a group of space scientists led by Bernard Quatermass, who have developed plans for the first Moon colony, learn that a secret, ostensibly government-run, complex of identical design has been built in a remote part of England and is the focus of periodic falls of small, hollow "meteorites" originating in outer space. Quatermass determines to investigate and uncovers a terrifying extraterrestrial life form which has already begun action to take over the Earth.

A mysterious artifact unearthed below a London subway station proves to have powerful psychic effects on the people around.