Following some trauma in her past that has since been repressed, a young woman is trying to recover her memories with the help of a psychiatrist. During her hypnosis sessions, she repeats the name "Tomie" but is unable to recall where she knows it from. Meanwhile, a police detective is investigating a string of brutal murders, where he also runs across the name "Tomie." How are the two connected?

Infected with Tomie's blood, a surgeon disappears, leaving his daughter, Yumi, to try to discover Tomie's identity and to solve the mystery of her father's disappearance.

Young art student Hideo paints an unnerving portrait of Tomie, who whispers that she loves him. Inexplicably, he reacts by stabbing her to death with a painting trowel. Two friends, Takumi and Shunichi, arrive on the scene and help him dispose of the body. To cheer him up, the boys take the unwitting murderer to the nearest bar for a party... but a mysterious girl named Tomie shows up, bearing a few odd physical resemblances to the dead girl in the ground.

Within days after the mysterious new student Kawagami Tomie joins a high school classroom, all hell literally breaks loose. Simple in-fighting between boys and girls over Tomie's oppressive shadow soon gives way to mind-breaking violence, culminating in a grizzly dissection that ultimately leads to suicide, insanity, and even more violence.

Tomie is a mysterious, beautiful girl you just can't get rid of. She will come to your life from nowhere, and whatever you do, kill her or love her, she will come back to you in the end.

Tsukiko is part of the photography club at school, but has always felt less than her sister Tomie. She's cute and very popular among boys. However, one day, Tomie dies in a horrible accident, triggering endless nightmares for Tsukiko. One year later, right when Tomie was supposed to turn 18, someone knocks on the door. Tomie is back.

A young woman named Kazue runs over a naked girl on a mountain road. When she stops to help, the girl runs off into an old abandoned house in the middle of the woods.

When a lonely high school girl befriends a strange, mysterious and beautiful girl, it is soon becomes clear that the two girls' meeting was not purely accidental.

A young, depressed man is trying to move on with his life after his girlfriend's bizarre death. One day, a mysterious woman notices him at work and convinces his coworkers to introduce him to her.