'Hell' is the name of the hero of the story. He's a prisoner of the women who now run the USA after a nuclear/biological war. Results of the war are that mutants have evolved, and the human race is in danger of extinction due to infertility. Hell is given the task of helping in the rescue of a group of fertile women from the harem of the mutant leader (resembling a frog). Hell cannot escape since he has a bomb attached to his private parts which will detonate if he strays more than a few hundred yards from his guard.

In the sequel to Hell Comes to Frogtown, the Mutant-Frog leader of Frogtown kidnaps a professor and forces him to make a serum that will turn everyone into Frogs, they also kidnap some people to test the serum on. And courageous Sam Hell will have to save them.

This film follows the lead character, Max Hell, who goes on a mission to rescue Dr. Trixi T from the clutches of the evil Mickey O'Malley.

Scott Shaw stars as the lone samurai, MAX HELL, on the trail of the serum which was unleashed to turn all of humanity into Toads.