On a flight transporting dangerous convicts, murderer Ryan Weaver manages to break free and cause complete chaos throughout the plane. As various people on board fall victim to Weaver, it is ultimately down to flight attendant Teri Halloran to keep the aircraft from crashing, with on-ground support from an air traffic controller. While Halloran struggles to pilot the plane, Weaver continues to terrorize the surviving members of the crew.

Rock superstar Slade Craven has decided to hang up his rock & roll shoes and has planned something very special for his final show -- instead of a typical concert in some sports arena, he'll play a set aboard a 747 jumbo jet, flying from Los Angeles to Toronto, with the gig broadcast live to millions of fans over the Internet. But what Craven didn't count on is the presence of a deranged fan with a gun who attempts to hijack the plane, throwing the show into chaos and putting the lives of everyone aboard the jet at risk.

A passenger of a hijacked airliner who happens to be an airplane engineer works to deactivate a chemical weapons bomb after the hijackers kill the pilot and threaten to kill all the passengers on the plane.