There is a war going on between Heaven and Hell. Earth is the battlefield. Human souls are the prize. On the front lines, where good and evil collide, is a soldier in search of his past and his future. Spawn, formerly known as Al Simmons, is a CIA hitman whose death causes him to seal a deal with the devil so that he can return to his wife Wanda. Instead, the devil transforms him into 'hell-spawn,' a dark warrior who battles the forces of evil on Earth--and in himself--to uncover the truth about his identity and fulfill his destiny.

Upon his return to "life", Spawn seeks out Wanda, who had apparently got over the grief of having lost Al and married another man, Al's best friend Terry Fitzgerald with whom she seemingly had a daughter, Cyan. Terry, a respectable man, works for a man named Jason Wynn. Wynn is a black-market arms dealer, amongst other things (such as the head of certain government organizations, one of which dispatched Al and his team to Vietnam), and is revealed to be the man responsible for the death of Al Simmons due to a disagreement the two had between each other. Jason's actions would also prove dangerous to the lives of Terry, Wanda and their daughter as well. Realizing that he is no longer the man in Wanda's life, Al swears to protect her and her new family.

Spawn is still on his quest to return to his love, Wanda, but is still in trouble. He is guided though by Cogliostro, who is the only one who can give him his humanity back.