Jeannie has been a happily married housewife for 15 years to her astronaut husband Tony Nelson and has a teenage son, T.J. When Tony is promoted to Colonel and is about to retire from the NASA space program, Jeannie decides to give him a celebration party in their backyard. However, egged on by his colleagues to retire with a dramatic flair, Tony breaks his promise to Jeannie for one more space flight (aboard the shuttle), this time with a female astronaut, Captain Nelly Hunt.

Col. Nelson is on a long-term, top-secret space mission. Jeannie cannot bring him home (temporarily) to hear their son's important academic presentation without knowing exactly where he is in the first place. The general in charge of the mission won't reveal anything. Things are further complicated when Jeannie's sister (Jeannie II) reminds Sham-Ir, the head of the genies, that a genie on Earth cannot go more than 3 months without an earthly master. (Col. Nelson is no longer Earthly, being in space.) Sham-Ir give Jeannie I a fortnight (14 days) to either find Col. Nelson or get a new master, a single male. (Col. Healy can't help, since he's now married.)