An ancient Egyptian priest named Imhotep is revived when an archaeological expedition finds his mummy and one of the archaeologists accidentally reads an ancient life-giving spell. Imhotep escapes from the field site and searches for the reincarnation of the soul of his lover.

A couple of young, out-of-work archaeologists in Egypt discover evidence of the burial place of the ancient Egyptian princess Ananka. After receiving funding from an eccentric magician and his beautiful daughter, they set out into the desert only to be terrorized by a sinister high priest and the living mummy Kharis who are the guardians of Ananka’s tomb.

A high priest of Karnak travels to America with the living mummy Kharis (Lon Chaney Jr.) to kill all those who had desecrated the tomb of the Egyptian princess Ananka thirty years earlier.

An Egyptian high priest travels to America to reclaim the bodies of ancient Egyptian princess Ananka and her living guardian mummy Kharis. Learning that Ananka's spirit has been reincarnated into another body, he kidnaps a young woman of Egyptian descent with a mysterious resemblance to the princess. However, the high priest's greedy desires cause him to lose control of the mummy...

After being buried in quicksand for the past 25 years, Kharis is set free to roam the rural bayous of Louisiana, as is the soul of his beloved Princess Ananka, still housed in the body of Amina Mansouri, who seeks help and protection at a swamp draining project.