Captured by smugglers when he was just a hatchling, a macaw named Blu never learned to fly and lives a happily domesticated life in Minnesota with his human friend, Linda. Blu is thought to be the last of his kind, but when word comes that Jewel, a lone female, lives in Rio de Janeiro, Blu and Linda go to meet her. Animal smugglers kidnap Blu and Jewel, but the pair soon escape and begin a perilous adventure back to freedom -- and Linda.

It's a jungle out there for Blu, Jewel and their three kids after they're hurtled from Rio de Janeiro to the wilds of the Amazon. As Blu tries to fit in, he goes beak-to-beak with the vengeful Nigel, and meets the most fearsome adversary of all: his father-in-law.