When local teacher Midori Yamabuki receives an emergency summons to her home planet it turns out to be a trap devised by galactic warlord Dr. Mashirito, and it's up to Dr. Senbei Norimaki and a group of students (including his robot daughter Arale) to venture into space to save her.

Professor Senbei finds a videotape of his deceased father providing instructions on how to create a love potion. The main ingredient is a tear of the evil Gyaasuka Daimao who lives at the Wonder Island. To retrieve it, Senbei takes Arale and Gatchan on a wacky adventure.

Dr. Mashirito and Abale-chan centers around Dr. Mashirito Jr. and his creation Abale, who serves as a rebellious opposite of the protagonist Arale. Many years after the end of Dr. Slump, Dr. Mashirito Jr. returns to avenge his father Dr. Mashirito, the sworn enemy of Senbei Norimaki. He makes an android at any point similar to Arale, except for her character that is somewhat different. He gives the name "Abale" to this android. In spite of itself, Abale will successfully contain an alien invasion.

The Norimaki Family, the Soramame Family, Suppaman, and Dr. Mashirito end up coming to a summer resort which is really a haunted castle filled with monsters. While enjoying the many facilities, such as the arcades and hot spring baths, they all end up falling into the clutches of Vandora, a female vampire who intends to feed off them.

Senbei Norimaki finds the secret treasure named “Eye of Rainbow” of the legendary Nanaba Castle in the mountain. This treasure makes every dream come true. When the gang of Arale Norimaki and Gatchan tried to steal the treasure, Bisna, who is the descendant of Nanaba Kingdom, takes the treasure. Bisna wants to revive the devil and Nanaba Kingdom. Arale and her friends went towards the secret Nanaba Castle to get back the treasure.

Arale and her friends learn of a World Grand Prix being organised by the Radial Kingdom. The prize is marrying Princess Front (a dead ringer to Ms. Yamabuki) or 1 million dollars. Of course they decide to enter for the money. Not so for Dr. Mashirito; he is going for the princess and will stop at nothing to win! The princess though has her own plan, which involves Ms. Yamabuki, and that of course means even Dr. Slump decides to enter with his trusty Borobo. Let the race begin...

Unable to entertain their princess Puruah, the kingdom of Yapaya requests professor Senbei to create a comedic robot capable of making her laugh for the first time in her life.

At the Penguin Village, the dinosaurs styled monster named Dodongadon appeared. But he was small as Arale and did not have strong power. Arale defeat him very easily, and Dodongadon called his mother Mamangadon. She was huge and had a big power. How Arale can defeat this big monster?

Arale and company arrive at a nice location for a picnic. They soon discover a beautiful stone with strange powers. Before they know it, a dangerous pirate and his mysterious ship invades their peace and steals the stone. Now it is up to them to retrieve the stone before it is used by evil hands.

While at the beach Arale Norimaki rescues a shark. In return, the shark invites her and the rest of the Norimaki to their underwater city. Meanwhile, Suppaman intends to follow them and get revenge. While in the city, Arale meets Urashima Tarō, who joins Arale while playing at the amusement park.

Children are lured to Metropolis only to find that the renowned, mythical city may not be the happy-go-lucky utopia they'd thought it would be.