Best friends Galleria, Chanel, Dorinda, and Aqua, A.K.A. the girl band "The Cheetahs," get the opportunity of a lifetime when they strut their way to Barcelona, Spain, to perform in an international music festival. Along the way, the "amigas Cheetahs" learn that, although their paths are not the same, they are lucky to have one another for the journey.

A four-member teen girl group named the Cheetah Girls go to a Manhattan High School for the Performing Arts and try to become the first freshmen to win the talent show in the school's history. During the talent show auditions, they meet a big-time producer named Jackal Johnson, who tries to make the group into superstars, but the girls run into many problems.

Chanel, Dorinda, and Aqua are off to India to star in a Bollywood movie. But when they discover that they will have to compete against each other to get the role in the movie, will the Cheetahs break up again?