In this continuation of "Family", it is discovered that the one who gave the order to assassinate the Mitsumikai Boss is the one and only Boss of the Japan Mafia: Mr. Nishiwaki. Hideshi finds something odd about the killing and begins to investigate, uncovering the true motives behind this murder. Miike's sequel is chock full of harrowing Boat chases, big explosions, beautiful women sex and drugs! Takashi Miike's Family, Part 2 continues the tale of the yakuza gangster named Hideshi, who must uncover the identity of the man who killed a powerful crime boss.

When the mobster Iwaida Nishikawi is executed by the hit man Takeshi, his family chases the killer. Takeshi's brothers Takashi and Hideshi Miwa try to find Takeshi, who is hidden with the nurse Rie Ishibashi, to protect him and Hideshi discovers that Takeshi was secretly sent by their Yakuza boss to eliminate Iwaida. Meanwhile, the mobster Kenmoshi abducts Takashi's wife Mariko and rapes her, trying to force Takashi to deliver his brother to him.