The corpse of a shabbily dressed young woman has been discovered in the mud flats of the Thames at low tide. Police assume she's a prostitute, but Dr. Watson suspects something more and goes to his old friend Holmes, now retired and at very loose ends.

Sherlock Holmes and Dr. Watson are called in to unravel a mysterious curse that has plagued the Baskerville family for generations. When Sir Charles Baskerville is found dead, his heir, Sir Henry, begs Holmes to save him from the terrifying supernatural hound that has brought fear and death to his household.