Chev Chelios, a hit man wanting to go straight, lets his latest target slip away. Then he awakes the next morning to a phone call that informs him he has been poisoned and has only an hour to live unless he keeps adrenaline coursing through his body while he searches for an antidote.

Chelios faces a Chinese mobster who has stolen his nearly indestructible heart and replaced it with a battery-powered ticker that requires regular jolts of electricity to keep working.