After avenging his family's brutal murder, Wales is pursued by a pack of soldiers. He prefers to travel alone, but ragtag outcasts are drawn to him - and Wales can't bring himself to leave them unprotected.

In a small, dusty border town, two long-time best friends of the mysterious gunman Josey Wales are brutally murdered by marauding rurales. The rurales, led by the beastial Commandante Escobar, head back to Mexico with gambler Ten Spot as hostage. Told of his friend's peril, Josey sets out on a trail of bloody vengeance.