Nathan Hayes is a religious man trying to hold onto his farm and keep his family in line. A real estate developer is trying to buy most of the farm property in the area, including Mr. Hayes family farm, in the hope that the Tennesse Valley Authority will choose the town for the site of a new dam and recreational area. The night of a terrible storm, an unidentified, glowing object crashes on the Hayes farm and with it comes a horrible curse for the Hayes family and the members of the community.

In the 17th century, an order of monks in Italy capture and entomb a demon that has possessed a member of their group. 400 years later, school teacher Elizabeth Magrino visits the monastery in order to do some research. What she and the current monks do not realize is that the evil hiding within the catacombs has unwittingly been released.

After a young man is bitten on the hand by a radioactive snake, his hand changes into a lethal snake head, which attacks everyone he comes into contact with. Also, his body becomes filled with snakes. Now, he must prevent himself from hurting others.

When an American plantation owner's wife and her sister interrupt an African death ritual to save the sacrificial goat, the witch doctor places a curse on them, summoning a god from the sea to slaughter them and anyone in its way with a panga, a curved, African machete.