Priest, a suave top-rung New York City drug dealer, decides that he wants to get out of his dangerous trade. Working with his reluctant friend, Eddie, Priest devises a scheme that will allow him to make a big deal and then retire. When a desperate street dealer informs the police of Priest's activities, Priest is forced into an uncomfortable arrangement with corrupt narcotics officers. Setting his plan in motion, he aims to both leave the business and stick it to the man.

A Harlem drug dealer and his girlfriend retire to Rome, where he joins an African revolution.

In this third entry in the Superfly films, Priest returns to New York from Paris to find who is responsible for his friend's murder. With a couple of new friends, he attempts to bring the killers to justice while trying not to get into criminal activity like he did years ago.