The Wishbone family are far from happy. In an attempt to reconnect as a family, they plan a fun night out. However, the plan backfires when they are cursed and all turned into Monsters.

To free Baba Yaga and Renfield from the clutches of Monster Hunter Mila Starr, the Wishbone Family once more transforms into a Vampire, Frankenstein's Monster, a Mummy and a Werewolf but when aided by their three pet bats, the Monster Family zooms around the world again to save their friends, make new monstrous acquaintances.