The conclusion to The Prophecy Trilogy. Once again, Christopher Walken returns as the Arch-Angel Gabriel. As the War in Heaven and on Earth rages on, Pyriel, the Angel of Genocide, rises to power, intending to destroy all of mankind. The only one who stands in his way is Danyael, who was born of an Angel and a woman.

In this direct-to-video sequel, Gabriel returns to try to destroy the human race he despises so much, with the help of a suicidal teen and the opposition of the angel Daniel.

The angel Gabriel comes to Earth to collect a soul which will end the stalemated war in Heaven, and only a former priest and a little girl can stop him.

There exists an ancient manuscript still writing itself called the Lexicon. It supposedly tells of the coming of the Anti-Christ, and happens to fall into the hands of an unsuspecting woman. Now, she is being pursued by angels intent on obtaining the information from the book.

In Bucharest, Allison is protecting the mysterious bible, "The Prophet Lexicon", where the last chapter about the apocalypse, called Revelations, discloses the name of the Antichrist in its last page. Meanwhile, the evil and jealous leader of the renegade angels Thrones, Stark, forces the hit-man Dylan to kill Allison to get the information about the Antichrist, but Dylan mysteriously feels attracted by the woman, protecting her against the Thrones. Allison seeks John Reigart for help, but Satan tell her that he is interested in the apocalypse to gather millions of souls to Hell. Alone and betrayed, Allison discloses the truth about her origins, while protecting the Lexicon.