The continuing adventures of Lilo, a little Hawaiian girl, and Stitch, the galaxy's most-wanted extraterrestrial. Stitch, Pleakley, and Dr. Jumba are all part of the household now, but what Lilo and Stitch don't know is that Dr. Jumba brought his other alien "experiments" to Hawaiʻi as well.

Lilo, Stitch, Jumba, and Pleakley have finally caught all of Jumba's genetic experiments and found the one true place where each of them belongs. Stitch, Jumba and Pleakley are offered positions in the Galactic Alliance, turning them down so they can stay on Earth with Lilo, but Lilo realizes her alien friends have places where they belong – and it's finally time to say "aloha".

As Stitch, a runaway genetic experiment from a faraway planet, wreaks havoc on the Hawaiian Islands, he becomes the mischievous adopted alien "puppy" of an independent little girl named Lilo and learns about loyalty, friendship, and ʻohana, the Hawaiian tradition of family.

Now, we find the rowdy extraterrestrial getting used to life with his new ʻohana. However, a malfunction in the ultimate creation of Dr. Jumba soon emerges, which reinstates his destructive programming and threatens to both ruin his friendship with Lilo and to short him out for good!