Nineteen year old pioneer woman Marty has recently married. She goes west with her husband Clem, hoping to start a new life. But Clem unexpectedly dies, and Marty finds herself alone, two months pregnant. Widower Clark offers her a marriage of convenience: she needs food and money, and he needs someone to take care of his daughter Missie. She accepts his proposal as a temporary solution.

In the 1800s frontier, Missie Davis is a bright and beautiful schoolteacher whose love for the prairie is matched only by her passion for books. When Missie encounters Grant, a handsome New England railroad executive, she feels as though she's met a hero from one of her novels.

The continued Westward journey of settlers Missie and Willie Lahaye. Their roots now firmly planted as they set up homestead in the far West, Missie begins to realize her passion for teaching as Willie cares for the couple's young daughter Kathy while expanding the family ranch with a little help from sons Jeff and Matthew. When the frontier railroad comes to town, the pleasure of a long-promised visit from Missie's father Clark is suddenly offset by the tragic death of young Kathy. As the untimely demise of their beloved daughter begins to drive an emotional wedge between Missie and Willie, the devastated father unexpectedly accepts an offer made by the powerful Samuel Doros to assume the role of town sheriff. Their faith shaken and their once close-knit bond suddenly torn asunder, Missie and Willie desperately attempt to bring their crumbling family back together as son Jeff faces a series of dangers while hopelessly falling for Doros' beautiful daughter Colette.

Missie's surprise pregnancy sets her on a new course that is both thrilling and terrifying. After all the planning and dreaming, she and her husband Willie are headed west in a covered wagon, leaving behind the prairie home of Missie's parents. Now, caught between the excitement of the new adventure and the pain of not knowing when she'll see her family again, Missie copes with the challenges, and cherishes the rewards, of her new homestead.

Missie three years later: being a single mother after her husband Willie was shot during a poker scuffle. She and Maddy move back in with her parents Clark and Marty. She finds a new home, and finds a new teaching position that she settles right into, but Missie has lost all faith in herself, until a chance encounter at her father's church where she adopts homeless orphan Belinda Marshall.

Centers on Missy's adopted daughter Belinda Tyler as she follows her dream. Belinda wants to be a doctor, but this time period does not look kindly on women with careers, especially one in the medical field. But Belinda is a strong-minded woman and deeply wants a career as a doctor. She manages to prove her abilities while assisting the local doctor and caring for an old woman who recently experienced a stroke. Belinda nurses her back to health and helps her regain the use of her arm again. Belinda also meets the nephew of their deceased neighbor. Drew comes to town to get his uncle's farm in shape to sell. After that he intends on returning to New York to join his father's law practice. He has no desire to stay in this small, unsophisticated town. But after meeting Belinda he has second thoughts. Belinda also feels something for Drew, but she is conflicted because she wants to be a doctor...

Belinda Simpson is now a doctor in a small Missouri town where an unknown plague is spreading fear and resentment amoung the townspeople. One local resident thinks the illness was spread from the town orphanage and wants to see it shut down. Belinda struggles to make sense of the disease and God's plan for the beleaguered town.

In this sequel, Lillian has been adopted and it's several years later. Annie, married and pregnant, visits her fellow doctor friend, Dr. Owen. Dr Owen desperately wants a baby, but seems unable to become pregnant. Lillian finds a love interest, an assistant to her adoptive dad, the latter has become quite overprotective.

Clark Davis adventurous dreams of seeing the world are put into jeopardy after he and a friend start a fight which damages a local cafe. Through a plea deal with the Sheriff and café owner Millie, Clark works off his sentence as a farmhand for the Barlow sisters, Ellen and Cassie. Older sister Ellen doesnt understand Cassies friendly nature with Clark; she agreed to the Sheriffs offer only because the farm has become too much to maintain alone. Clark is slowing winning Ellen over, but suddenly suffers a traumatic head injury in a fall. After Ellen nurses him back to health, her former fiancé returns to win her back. Will Clark travel on or stay behind where love begins?

Clark Davis struggles to maintain his land and support his family during a long drought. With a bank loan to repay, his wife, Ellen, takes a job in town as a seamstress, but soon becomes ill with scarlet fever. Devastated to lose his beloved wife, Clark and his young daughter Missie turn to his parents Irene and Lloyd for support. Clark must find a way to save his farm and survive Ellen's death without losing the person he loves most: his daughter.

While still mourning the loss of her husband and daughter, recently widowed Ellie King visits her brother Aaron Davis and his children for Christmas. Ellie does her best to enjoy the holidays, even making new friends with Mrs. Thompson, a local shop keeper, and handsome admirer Deputy Strode. Settling in nicely with her brother's family, Ellie also meets Erik, a young man abandoned by his outlaw father whom Aaron has taken in as one of his own. When Aaron travels out of town to purchase adjacent land for farming, Ellie agrees to watch his children, but the season’s festivities are threatened when Aaron goes missing.