Grisly strangulations in London alert Nayland Smith of Scotland Yard to the possibility that fiendish Fu Manchu may not after all be dead, even though Smith witnessed his execution. A killer spray made from Tibetan berries seems to be involved and clues keep leading back to the Thames.

This time Fu Manchu and his army of henchmen are kidnaping the daughters of prominent scientists and taking them to his remote island headquarters. Instead of asking for ransom, Fu demands that the fathers help him to build a death ray, which he intends to use to take over the world. But Fu's archenemy, Nayland Smith of Scotland Yard, is determined not to let that happen.

In his remote China hideaway the evil Fu Manchu plots the death and discredit of his arch rival, Inspector Nayland Smith of Scotland Yard.

Fu Manchu inoculates ten women with poison, to kill ten world leaders.

The evil mastermind Fu Manchu plots his latest scheme to basically freeze over the Earth's oceans with his diabolical new device. Opposing him is his arch-nemesis, Interpol's very British Nayland Smith.