As the purged Cardinals are dismissed and stripped of their titles and wealth, one of them angrily sets the Vatican treasury ablaze. Incensed by the new King Ferdinand’s arrogant refusal to accept Giovanni as Lucrezia’s child, Cesare travels to Naples to fix the problem. After Lucrezia and Alfonso’s wedding, Alfonso realizes that the political sands are shifting - and not in his favor. Upset, he abandons Lucrezia alone on their wedding night, driving her into the arms of someone else.