As the city of Seattle revels at the Phoenix Fair celebrating the city’s rebirth post-COVID, the Grey Sloan doctors treat a patient who encounters illegal fireworks. Meanwhile, Bailey has her sights set on hiring new doctors, but she’s having trouble finding viable options. Owen and Teddy attempt to take the next step in their engagement, and Meredith has a surprising opportunity when she meets a dynamic doctor from her mother‘s past. The crossover starts on Station 19 S05E01 Phoenix from the Flame.

Meredith seeks advice from Amelia. Meanwhile, Richard is reenergized as he takes teaching to a new level at the hospital, and Winston treats a patient suffering from kidney failure.

Seattle’s favorite redhead returns and graces the Grey Sloan halls with her experience and expertise as she attempts to help Richard teach the newest crop of residents. Meanwhile, Meredith has a decision to make, and Link confides in Teddy.

Richard recruits Meredith and Bailey to help him launch a new program. Addison's patient has complications from a procedure. Jo helps a woman who goes into premature labor.

Part 2 of a crossover with “Station 19” which starts on S05E05 ”Things We Lost in the Fire.” The Grey Sloan doctors spring into action after an explosion rocks Seattle, with the incoming trauma hitting close to home. Owen experiences PTSD after he hears the explosion, while his sister Megan enlists help from Winston and Hayes in confidence. In Minnesota, Meredith and Amelia meet up with a familiar face who assists in their study.

It’s Thanksgiving and while Meredith faces travel complications due to the weather, Nick steps in to help in more ways than one. Meanwhile, Richard and Bailey seek out emergency surgeries, and Amelia and Link reconnect.

Dr. Hamilton takes his frustrations out on Meredith, so Nick gives her a chance to blow off steam by scrubbing in on a surgery. Back in Seattle, Link and Jo take their kids to a fairytale theater performance that goes wrong. Bailey and Dr. Lin attend a recruitment fair in hopes of attracting more doctors to Grey Sloan but find themselves ill-prepared.

The doctors of Grey Sloan Memorial celebrate the holidays; Hamilton and Meredith prepare for a milestone on their project; Link wants to spend the holiday with Amelia and Scout as a family; Schmitt is faced with a difficult decision during surgery.

The Grey Sloan Memorial doctors grapple with the aftermath of the car crash that involved some of their own; Meredith works to save Dr. Hamilton's life. Levi is impacted from his latest loss. Part 2 of a crossover with “Station 19” which starts on S05E09 ”Started from the Bottom”

Schmitt must face the Morbidity and Mortality conference. Meanwhile, Meredith convinces Nick to scrub in on a surgery in Seattle, and Jo faces her feelings.

While Meredith, Amelia and the team prepare for Dr. Hamilton’s long-awaited, groundbreaking surgery, Bailey receives an unexpected offer. Owen’s impatience makes him a difficult physical therapy patient, forcing Link to intervene. In Minnesota, Nick makes a liver transplant a teaching moment.

Nick whisks Meredith away to his Minnesota cabin for a romantic weekend, leaving Winston and Maggie to care for Meredith’s children. Meanwhile, Amelia and Kai grow closer.

While Richard ponders his surgical abilities, Jo is charmed by her patient’s brother. Elsewhere, Megan makes sure Teddy and Owen talk out their differences, and a pet python causes an uproar.

Tensions at Grey Sloan Memorial rise as the effects of the physician shortage begin to show. Meanwhile, Meredith struggles to step away from work as she spends a sick day at home with Zola, and the hospital receives an unexpected visitor.

Bailey is on edge when an accreditation council stops by Grey Sloan to review the residency program, while Richard sets an assessment of his own for the same day. Meanwhile, Nick returns to Seattle to perform a first-of-its-kind operation with Meredith.

Bailey faces an unhappy Catherine who is facing audits for several of her Foundation hospitals. Meanwhile, Addison is back at Grey Sloan; tensions rise between Meredith and Richard, and Owen returns to work.

A former patient of Link’s, Simon, is in the ER with his pregnant wife; and Bailey receives an offer from Nick.

A dinner party is thrown at the sister house in Nick’s honor. Meanwhile, Grey Sloan Memorial receives a victim of a brutal hate crime.

Due to a blood shortage, Grey Sloan Memorial is setting up a voluntary donation center. Meanwhile, Nick asks Meredith for help with his patient and Winston is hung up on his relationship with his brother.

The blood shortage at Grey Sloan Memorial continues. Meanwhile, Meredith makes a risky decision regarding a patient, and Owen’s actions to help his fellow veterans come to light.