A high school student develops an ability after injecting promicin. Tom visits Isabelle in jail, while Diana searches for her missing sister. Following the advice of a young woman, named Cassie, Kyle is able to wake Shawn from his coma. Jordan Collier's conscience gets to him. Meanwhile, NTAC gets a new director.

Tom and Diana search for someone who has the ability to make people's worst fears come true. Danny seeks Shawn's help to find a promicin shot. Meanwhile, Cassie leads Kyle to a book that contains a prophecy about Jordan Collier.

An elderly woman develops the ability to astral project unseen by others, but she is stuck in limbo when her body is murdered, and she must find a way to contact Tom and Diana to help catch her killer. Elsewhere, Shawn decides to start healing people again despite threats.

April's new ability takes her in a danger. Meanwhile, Shawn is approached to run for public office. Kyle helps Isabelle.

Tom tracks Jordan to a small town, where he meets a woman who can relieve people's stress by talking to them. Meanwhile, Marco and Diana have a nice talk. Maia's visions are giving her nightmares.

Jordan wants Shawn to rejoin the movement. Meanwhile, a 4400 with an amazing ability disappears.

When Jordan Collier and his followers seize control of most of Seattle, the government sends a Delta Force of enhanced soldiers to capture Collier dead or alive.

P.J. took the Promicin shot 2 months ago. Now he has an ability...

Richard returns from hiding to abduct Isabelle from Promise City, hoping to "start over." Meanwhile, Tess, her schizophrenia out of control, uses her ability to take control of a diner full of people.

Tom and Diana look for Richard, but Tom is distracted by his dreams about the future. Meanwhile, Collier is threatened by Shawn's test that could determine who would die from a Promicin shot.

Tom and Diana must race to find the source of a computer virus that could bring down Ubient software, one of the world's largest software companies that is run by suspected member of the marked, Drew Imroth. Meanwhile, Maia visits Promise City where she receives an unexpected birthday surprise: a visit from her birth parents.

Meghan and Diana learn how to remove the entity from Tom, but the procedure is dangerous. Meanwhile, Shawn finds help in his attempt to rescue Kevin from Promise City; and Jordan is betrayed by someone close.

Paramedics try to resuscitate Susan Farrell. They believe that she took promicin and lost the 50/50 lotto that comes with it. Danny is certain that she did not take the shot. After arriving at the hospital with the paramedics, things get complicated as everyone around Danny start to die. Garrity and another NTAC agent are sent to the hospital to assess the situation.