Sketches include: Eye on Pittsburgh, "Bottom of Your Face", My Mom Married Kenan Thompson, The Drew Barrymore Show, Weekend Update, NBA Bubble Draft Finals, Stunt people

Jack White performs a medley of "Ball and Biscuit", "Don't Hurt Yourself" and Blind Willie Johnson's "Jesus is Coming Soon" for his first set and "Lazaretto" for his second. Jim Carrey and Maya Rudolph appear as Joe Biden and Kamala Harris, respectively, in the cold open; as Biden, Carrey also appears as Jeff Goldblum and Seth Brundle, Goldblum's character from the 1986 film The Fly. Jason Momoa appears in the pre-recorded "Enough is Enough" sketch. The episode pays multiple tributes to Eddie Van Halen, who had died earlier in the week: footage of him performing with the Robert Cray Band from season 12 is shown before the goodnights, White uses a guitar designed especially for him by Van Halen during his performance of "Lazaretto", and Burr wears a Van Halen shirt during the goodnights.

Sketches include: BonjourHi!, 5-Hour Empathy, Sharon, Weekend Update, Your Voice Chicago, Funk Jam!, Jack Flatt's, reBay

Sketches include: Psychic, The Haunted Manor, The Bachelor, Trump Addicts of America, Weekend Update, Visiting Grandma, Africa, Ass Angel Perfume Jeans

Sketches include: The Birds, Strollin', The Headless Horseman, Thank You NYC, Weekend Update, Big Nick's Souvenirs, Brenner Goods

Sketches include: Ad Agency, Mario Memories, Take Me Back, Weekend Update, Centre 5 News Albany, DC Morning

Sketches include: Meagan, Stanta, Duplex, The Christmas Conversation, Ghosts of Morgan Wallen Future, Weekend Update, Santa's Village, Kills the Bit

Sketches include: A Rona Family Christmas, A December to Remember, The Dionne Warwick Talk Show, The Farm, Weekend Update, Holiday Baking Championship, Yeet, Sportsmax

Sketches include: Secret Word, Christmas Morning, Christmas Eve 1944, A Teacher, Home Alone 2: Lost in New York, Weekend Update, Ménage a Grinch, Sue surprise

Sketches include: Blue Georgia, Damian, The Dividend, Now That's What I Call Theme Songs Sung by the Stars of the Show, Warren Street COVID Bubble, Weekend Update, Supermarket Sweep, Subway, Sex Ratatouille

Sketches include: Universal Studios Tram Tour, Zillow.com, Super Bowl Party, Lifting Our Voices, Weekend Update, Football Songs, Carrie's Wedding, It Gets Better

Sketches include: What's Your Type?, Pelotaunt, Gorilla Glue Beauty Products, Women Who Drink a Lot, The Negotiator, Weekend Update, The Rider, Fem Box

Sketches include: Actors Spotlight, "LOCO", "Driver's License", Mr. Chicken Legs Pageant, The Job Interview, Weekend Update, Songs of the Sea, Blessed, Bridgerton Intimacy, "The Grocery Rap"

Sketches include: Mirror Workout, Murder Show, Cinderella, Boner Next to My Friends, Weekend Update, Viking Voyager, The Dionne Warwick Talk Show, Singles at a Bar

Sketches include: Hot Ones, Boomers, A Kamala Harris Unity Seder, NFTs, Weekend Update, Richard Perquest & Tanya Katank, 2021 Barfly Awards, The Maya-ing

Sketches include: Vaccine Game Show: Will You Take It?, Viral Apology Video, Scattergories, Proud Parents, Weekend Update, Frat Trip, Dog Park, Half Brother

Sketches include: What's Wrong with This Picture?, Tremfalta, Chrissie and Josh, Weird Little Flute, Weekend Update, Starcharter Andromeda, Lesbian Period Drama, The War in Words, Beat Buddies

Sketches include: Gen Z Hospital, Every Conversation with People You Haven't Seen Since Quarantine Started, The Ooli Show, Murdur Durdur, Weekend Update, Mario Brothers Trial, The Astronaut, Earl

Sketches include: Braxton High School Prom Red Carpet, The Last Dance: Missing Scene, The Muppet Show, Gene's Sad Birthday, Weekend Update, George Gershwin Tribute, Hold Your Applause

Sketches include: Hollywood Squares, Gun Dad Meme Sketch, Heaven, It's Pride Again, Celtic Woman, Weekend Update, Enid & Astrid's Brawr Barn, Roommates in the City NYU Panel, The Movies