It's the second semester at P.C.A. Dana left for the European Exchange Program so, Zoey and Nicole need a new roommate. When they come back to their dorm a gothy, freaky girl named Lola, who in the episode drinks raw eggs and tries to pierce herself. is in their room and learns that Lola is their new roommate. Meanwhile, Michael and Chase have to deal with Logan, who goes completely overboard on the entertainment system for their new dorm room.

Mr Bender decides to have each person in his class put an item that best represents them into a time capsule. Chase is desperate to know what Zoey has said about him in the video she made to put in the time capsule, and will go to any lengths to find out. Also, Nicole tries to help Quinn to stop snoring.

It's election time again, class presidents have to be voted for and Chase and Zoey end up nominating each other. Then they make pact of whatever happens, they promise that the election won't affect their friendship. But then later on, things get spicy between them.

Every Halloween at PCA, the secondary makes a haunted house for the lower school. This year, Logan is in charge. He promises everybody that the haunted house will not just make them scream but it will make them cry. But when Dustin and his roommate, Jack, get "lost" in the haunted house, Logan starts to get scared and starts to wonder where Dustin and his roommate have gone. Michael gets chased all over PCA by some French tourists who think he is ill, and Nicole gets a case of mistaken identity when she chases Mark. Lola did not appear in this episode.

Dustin's new girlfriend, Trisha Kirby (Jennette McCurdy), turns out to be a very naughty girl. Zoey sends Chase to persuade Tricia to stop going out with Dustin and go for someone older. She gets the wrong idea and Trisha and Chase are boyfriend and girlfriend. Oops. so Chase and Zoey pretend to be girlfriend and boyfriend . Meanwhile, Michael tells Logan about his crush on Lola and end up getting sprayed by a skunk.

Chase and Michael start an online show, The Chase & Michael Show. Zoey and Logan have their own segment on it called "He Says, She Says" and it all goes wrong when all the boys and girls begin fighting, so Dean Rivers cancels their show. Meanwhile, Nicole is depressed because she is failing Algebra because of cute boys, so Quinn and Lola try to fix her problem by using a hypnotis technique.

The girls can no longer relax on the boy's dorm roof, thanks to Logan. To solve this problem, they must prove that boys can act the same with girls around. So, they transform Lola into 'Steve' and Steve goes to live with Chase and Logan.

Zoey challenges some computer geeks to a Bot battle, but first they must build a Bot to compete. So the gang asks Quinn for help, but when Logan makes fun of her and everyone laughs, she decides not to help. So, they ask the smartest guy at PCA to help, but on one condition: Nicole must go on a date with him.

When Lola develops a crush on Chase, Zoey and Chase are forced to address their relationship. With some advice from Michael, Chase decides to say "yes" to the date and forgets all the things that he planned to do with Zoey. This makes Zoey feel jealous and upset. Meanwhile, Logan teaches Dustin how to impress the ladies.

Spring Break-Up is the first Zoey 101 TV movie and the movie is about Zoey and the gang going to Logan's Beach House for Spring Break finding out that they are on the testing of Logan's dads new show called: "Gender Defenders". Meanwhile, Chase sends a text message by mistake to Zoey confessing his love for her.

Zoey and the gang go to Logan's beach house for Spring Break and finding out that they are on the testing of Logan's dad's new show called "Gender Defenders". They compete in many challenges to see which team, the boys or the girls, wins. It is then revealed that both teams are already on the show, and it has been filming by hidden cameras. The gang then throws a party for the first airing of the show. At the party, Chase decides to get over his fear of telling Zoey of his love for her. He then sends her a text saying "I love you." After this, we see that Zoey left her communicator, which were given to all of the contestants on "Gender Defenders" sitting on a ledge next to a fountain. Zoey's communicator receives the message, but is knocked into the water fountain because it was set to vibrate. In the last scene, Chase sees that Zoey does not have her communicator and wonders where it is, but does not find out.

After a fire burns down Sushi Rox, Zoey and the gang hold a people auction to raise money in order to rebuild it. Chase and Michael get auctioned to the sushi-crazy gym teacher. Zoey, Lola, and Nicole become Logan's personal cheerleaders, and they are told to "cheer his awesomeness", as in cheer for everything he does. His plan backfires when the girls decide to cheer for everything he does.

Quinn's pet alpaca, Otis, is depressed because he misses her, leaving her feeling depressed as well. The girls then decide to try and cheer her up by throwing an alpaca-themed party. However, this only made her miss Otis even more and she left PCA to meet with him, which could get her suspended as it is the middle of the semester. Meanwhile, the guys make a bet to see who can go the longest without saying anything containing the letter 'S' and the person who loses has to run across the campus wearing nothing but a bikini top, a hula skirt, and a flashing red helmet.