Adam Rutherford meets a new creature created by American scientists, the spider-goat. It is part goat, part spider, and its milk can be used to create artificial spider's web. It is part of a new field of research, synthetic biology, with a radical aim: to break down nature into spare parts so that we can rebuild it however we please. This technology is already being used to make bio-diesel to power cars. Other researchers are looking at how we might, one day, control human emotions by sending 'biological machines' into our brains.

Like many, Michael Mosley want to get fitter and healthier but can't face hours on the treadmill or trips to the gym. Help may be at hand. He uncovers the surprising new research which suggests many of us could benefit from just three minutes of high intensity exercise a week. He discovers the hidden power of simple activities like walking and fidgeting, and finds out why some of us don't respond to exercise at all Using himself as a guinea pig, Michael uncovers the surprising new research about exercise, that has the power to make us all live longer and healthier lives.

Scientists are expecting a fit of violent activity on the sun which will propel billions of tonnes of superheated gas and pulses of energy towards our planet. They have the power to close down our modern technological civilization. Horizon meets the space weathermen who are trying to predict what's coming our way, and organistions like the National Grid which are preparing for the impending solar storms.

We all like to think we are in control of our lives - of what we feel and what we think. But scientists are now discovering this is often simply an illusion. Surprising experiments are revealing that what you think you do and what you actually do can be very different. Your unconscious mind is often calling the shots, influencing the decisions you make, from what you eat to who you fall in love with. If you think you are really in control of your life, you may have to think again.

Surgeon Gabriel Weston discovers the surprising truth about why so many people are piling on the pounds, and how to fight the fat epidemic. She discovers the hidden battles of hormones that control people's appetites, and sees the latest surgery that fundamentally changes what a patient wants to eat by altering how their brains work. Gabriel is shocked to find out that when it comes to being overweight, it is not always your fault you are fat.

Something weird seems to be happening to our weather - it appears to be getting more extreme. In the past few years we have shivered through two record-breaking cold winters and parts of the country have experienced intense droughts and torrential floods. It is a pattern that appears to be playing out across the globe. Hurricane chasers are recording bigger storms and in Texas, record-breaking rain has been followed by record-breaking drought. Horizon follows the scientists who are trying to understand what's been happening to our weather and investigates if these extremes are a taste of whats to come.

Marcus Du Sautoy wants to find out how close we are to creating machines that can think like us: robots or computers that have artificial intelligence. His journey takes him to a strange and bizarre world where AI is now taking shape. Marcus meets two robots who are developing their own private language, and attempts to communicate to them. He discovers how a super computer beat humans at one of the toughest quiz shows on the planet, Jeopardy. And finds out if machines can have creativity and intuition like us. Marcus is worried that if machines can think like us, then he will be out of business. But his conclusion is that AI machines may surprise us with their own distinct way of thinking.

Over the past year, Horizon has been behind the scenes at one of Britain's leading cancer hospitals, the Royal Marsden in London. The film follows Rosemary, Phil and Ray as they undergo remarkable new treatments - from a billion pound genetically targeted drug designed to fight a type of skin cancer, to advanced robotic surgery. We witness the breakthroughs in surgery and in scientific research that are offering new hope and helping to defeat a disease that more than one in three of us will develop at some stage of our lives.

Plastic surgeon Dr Rozina Ali leaves the operating theatre behind for the frontiers of skin science and asks if it is possible to make your skin look younger without surgery. She discovers the latest research about how the foods we eat can protect our skin from damage, and how a chemical found in a squid's eye is at the forefront of a new sun protection cream. She also finds out how sugar in our blood can make us look older, and explores an exciting new science called glycobiology, which promises a breakthrough in making us look younger.

Horizon goes behind the scenes at Nasa as they count down to the landing of a 2.5 billion-dollar rover on the surface of Mars. The nuclear-powered vehicle, the size of a car, will be winched down onto the surface of the red planet from a rocket-powered crane. That's if things go according to plan; Mars has become known as the Bermuda Triangle of space because so many missions there have ended in failure. The Curiosity mission is the most audacious, and expensive, attempt to answer the question of whether there is life on Mars.

Michael Mosley has set himself a truly ambitious goal: he wants to live longer, stay younger and lose weight in the bargain. And he wants to make as few changes to his life as possible along the way. He discovers the powerful new science behind the ancient idea of fasting, and he thinks he's found a way of doing it that still allows him to enjoy his food. Michael tests out the science of fasting on himself - with life-changing results.

Cosmologists talk about their project to create a map of everything in existence, and also reveal that their research has some highly unexpected results, creating a picture stranger than anything they had ever imagined.

Horizon plunges down the biggest rabbit-hole in history in search of the smallest thing in the Universe. It is a journey where things don't just become smaller but also a whole lot weirder. Scientists hope to catch a glimpse of miniature black holes, multiple dimensions and even parallel Universes. As they start to explore this wonderland, where nothing is quite what it seems, they may have to rewrite the fundamental laws of time and space.

Across the world we are seeing the emergence of bacteria that have gone rogue. These are the superbugs, dangerous bacteria that are becoming resistant to our only defense; antibiotics. Horizon meets the scientists who are tracking the spread of these potential killers around the globe, and discovers the new techniques researchers are developing to help defeat these superbugs.

Is there any way to slow or even prevent the ravages of time? Veteran presenter Johnny Ball looks back over the 45 years that Horizon - and he - have been on air to find out what science has learned about how and why we grow old. Charting developments from macabre early claims of rejuvenation to the latest cutting-edge breakthroughs, Johnny discovers the sense of a personal mission that drives many scientists and asks whether we are really any closer to achieving the dream of immortality.

Dallas Campbell looks back through almost 50 years of the Horizon archives to chart the scientific breakthroughs that have transformed our understanding of the universe. From Einstein's concept of spacetime to alien planets and extra dimensions, science has revealed a cosmos that is more bizarre and more spectacular than could have ever been imagined. But with every breakthrough, even more intriguing mysteries that lie beyond are found. This great journey of discovery is only just beginning.