Randy comes to terms with his role in the COVID-19 outbreak as the on-going pandemic presents continued challenges to the citizens of South Park. The kids happily head back to school but nothing resembles the normal that they once knew; not their teachers, not their homeroom, not even Eric Cartman.

The citizens of South ParQ are clamoring for the COVID-19 vaccine. A hilarious new militant group tries to stop the boys from getting their teacher vaccinated.