The story of a little creature created by genetic experimentation and bound to prison with his evil creator. Stitch escapes and heads for Earth where he tries to impersonate a dog and gets adopted by little Lilo, whom, bent on self preservation, he plans to use as a human shield to protect him for the aliens sent to recapture him. But without a greater purpose in life, no friends, family or memories, Stitch does a little soul searching and begins to understand the meanings of "love" and "family" and his feeling for Lilo begin to change.