The story of a little creature created by genetic experimentation and bound to prison with his evil creator. Stitch escapes and heads for Earth where he tries to impersonate a dog and gets adopted by little Lilo, whom, bent on self preservation, he plans to use as a human shield to protect him for the aliens sent to recapture him. But without a greater purpose in life, no friends, family or memories, Stitch does a little soul searching and begins to understand the meanings of "love" and "family" and his feeling for Lilo begin to change.

Taking place between the original "Lilo and Stitch" and "Stitch: The Movie", "Lilo and Stitch 2" finds the rowdy extraterrestrial getting used to life with his new ohana. However, a malfunction in the ultimate creation of Dr. Jumba soon emerges, which reinstates his destructive programming and threatens to both ruin his friendship with Lilo and to short him out for good!

The pilot episode. The film starts out with ex-Captain Gantu on his new spaceship (his original got destroyed in the first film), being hired by Hämsterviel to retrieve the experiments. Meanwhile, on Earth, Stitch is still not fitting in. Lilo tries to encourage him by saying he's one-of-a-kind, comparing him to Frankenstein. Naturally, that just makes him feel worse. Suddenly, a crash is heard from below. Running downstairs, the pair encounters Gantu, breaking into their home. In the ensuing chaos, Gantu finds and takes a blue ball with the number "625" on it before abducting Jumba for interrogation. Lilo and Stitch manage to take Jumba's ship to chase Gantu into space and engage him in battle, before being defeated and falling back towards Earth. Back at the house, Lilo, Stitch and Pleakley talk and find the container Jumba was hiding. Pleakley decides that these are the other experiments, in dehydrated form. He warns them not to tell anyone or put the experiments in water. Delibe

Lilo, Stitch, Jumba and Pleakley have finally caught all of Jumba's genetic experiments and found the one true place where each of them belongs. Stitch, Jumba and Pleakley are offered positions in the Galactic Alliance, turning them down so they can stay on Earth with Lilo. But Lilo realizes her alien friends have places where they belong, and it's finally time to say "aloha." Meanwhile, Gantu has left Earth and broken Doctor Jacques Von Hamsterviel out of prison, who's planning to create and clone a new experiment named "Leroy," one that will allow him take over the galaxy.