This episode recaps all of the seasons of Grey's Anatomy and sets up the spin-off series, Private Practice, by relating Addison's story. It also includes a preview of Private Practice.

Addison goes on a road trip to LA as she is given another job offer in California, although she finds that no matter where she is, drama follows her. While in LA, she helps resolve a surrogacy problem, where it seems the surrogate had unprotected sex with many other guys on the week she was implanted with the fertilized egg. Meredith continues to improve her relationship with her father and step-mother when her step-mother is brought to the hospital. Cristina is having issues coping with her mother and (soon-to-be) mother-in-law.