In the eighth season premiere, the Camden's spend the last week of summer at a beach house. At the beginning of the summer, Simon killed Paul Smith in an automobile accident. Simon is having a hard time dealing with the fact that he killed him and everyone tries to help him. Eric and Annie try to push Simon to go back to school which begins in a week. Eric would like Paul's parents (guest-stars Katie Mitchell and Mark Moses) to accept the insurance companies offer to the money. Paul's brother vandalizes the church by adding graffti to the sign saying "Thou Shalt Not Kill." Simon runs away to New York to get away from the troubles he is having in Glen Oak. Also, Lucy and Kevin discuss possibily having a child. Peter is spending a lot of time around Ruthie and the Camden family. Ruthie finds out about Mary and Carlos being married.

Mary (guest-star Jessica Biel) makes a surprise visit home to deliver unexpected news to Eric and Annie. Meanwhile, Simon tells Cecilia (Ashlee Simpson) that he needs space. Also, Lucy and Kevin adjust to married life. Chandler breaks up with Roxanne after learning that she isn't comfortable with the idea of being a preacher's wife, while Roxanne seeks Kevin's advice on dealing with a dispirited Chandler. Also, the Camdens finally learn who's pregnant. Lastly, Eric ponders Simon's academic future and Annie prepares for a potentially tense dinner engagement.

With Annie out of town, Eric is left alone to accompany Simon on his visit to the Board of Education to discuss early graduation. During the meeting, Simon bonds with his advisor, Maynard (guest-star Cirroc Lofton), when they realize that they're both preachers' kids. Meanwhile, Lucy catches Chandler kissing a beautiful blonde woman at church and she agonizes over whether or not to tell Roxanne; Kevin's (George Stults) boss, Detective Michaels (guest-star Christopher Michael), tricks him into babysitting his six-year-old granddaughter; Peter makes a deal with the school bully in an attempt to protect Ruthie and Cecilia agrees to watch the twins which leads to a confrontation with Simon.

When a mysterious stranger, Martin (Tyler Hoechlin), wanders into the Camden home and spends the day with the family everyone assumes he is Simon's friend. Meanwhile, a disheveled, Rabbi Glass (Richard Lewis) stops by to confide in Eric that he caught his wife (Loraine Newman) kissing another man and discusses about splitting up. Kevin feels emasculated after being attacked and injured by a woman during a domestic disturbance call and goes on medical leave. His attitude toward Lucy changes drastically as he worries that Lucy isn't attracted to him anymore. Plus, Simon is concerned that no one seems to care that he's leaving for college in a couple of days. Lastly, Ruthie and Peter struggle with a school project.

In a video essay for his application to college, Simon (David Gallagher) recounts the experiences of his Camden family members including their relationships, friends and mistakes that they've made over the years in Glen Oak as well as his own pain at having killed Paul, a young boy in a car accident earlier in the year.

During his Sunday sermon, Eric proposes that instead of a financial contribution, everyone should make a commitment to reach out and help someone in need. Kevin suggests that he and Lucy work together to set up a neighborhood watch program, but she feels passionate about working with Habitat for Humanity. Eric calls his new son-in-law Carlos (guest-star Carlos Ponce) and asks him to fly in without Mary for dinner with the family, which makes Carlos very nervous. Also, Ruthie picks a shy new girl at school as her project and soon finds out that she has a secret. Meanwhile, Peter picks Ruthie as his project, which prompts her to tell him that they should spend less time together. Chandler and Roxanne keep running into each other stirring up old feelings. Lastly, Annie becomes jealous of all of the time the twins are spending with Cecilia.

Eric and Annie throw a "Welcome to the Neighborhood" party for Ruthie's Muslim friend Jill Dupree (guest-star Randa Sabbah) and her parents (guest-stars Kamal Marayati and Yareli Arizmendi), but the Duprees are hesitant to attend. Eric is shocked and disappointed when he learns that his neighborhood is not a friendly place for Muslims. Meanwhile, Cecilia's house is robbed while she and her dad (guest-star Brad Maule "General Hospital") attend Kevin's first Neighborhood Watch meeting; Roxanne mentors a troubled 16-year-old (guest-star A.J. Trauth) and suspects that he might be involved in the robbery, and Chandler finds himself attracted to Peter's mom Paris (guest-star Shannon Kenny).

Eric arranges for Peter and his dog to visit a drug rehab center to cheer up the patients. Peter bonds with Nick (guest-star Joe Penny) and helps him reconnect with his estranged son. Meanwhile, a very uncoordinated Lucy finds out that Kevin has been secretly coaching the Glenoak Police Department husband-and-wife softball team and demands that she be allowed to play. Just before his first date with Paris (guest-star Shannon Kenny), Chandler receives a letter from Roxanne telling him she still loves him. Martin (guest-star Tyler Hoechlin) confronts Cecilia about her lingering feelings for Simon, prompting Ceclia to call Simon to let him know she has a new boyfriend. She is also surprised when he admits that he is also dating someone and Ruthie is jealous of Cecilia and Annie's close relationship.

Eric (Stephen Collins) is brought in by the school board to help investigate the local high school Principal, Ms. Jones (guest-star Meredith Baxter), when more than one concerned parent questions her behavior. When a female student disappears, all fingers point at Ms. Jones, but Eric believes strongly that the student's father may be the real culprit. Elsewhere, rumors about Martin (Tyler Hoechlin) upset Cecilia, who then regrets talking to Ruthie about her feelings.

Matt (guest-star Barry Watson) and Sarah (guest-star Sarah Danielle Madison) begin their student rotation in the ER, but get off to a bad start by arriving late and angering Dr. Norton (guest-star Dennis Boutsikaris), the attending ER physician. Matt and Sarah's relationship is tested when Matt quickly demonstrates an aptitude for the work, but Sarah accuses him of trying to make himself look better than the other students, especially her. However, Matt ends up looking foolish when he can't figure out how to turn off the ringer on his cell phone and he gets stuck fielding calls from his family. Matt's day ends tragically, leaving him to question his destiny.

Matt (guest-star Barry Watson) returns home to tell Eric and Annie that Sarah has left him and he's dropping out of medical school. Rabbi Glass offers Matt marital advice. Meanwhile, Kevin must decide whether or not to tell a very jealous Lucy that his ex-wife (guest star Mindy Burbano) is in town and they got invited to dinner with her. Martin's aunt (guest star Keri Lynn Pratt) asks Eric to step in and talk Martin into moving to New York with her and Chandler asks Peter how he would feel about Chandler marrying his mother someday. Peter thinks something is amiss when his mother goes out of town for a business trip. Ruthie keeps something from her mother.

A distraught Peter learns that his alcoholic and mean-spirited father, Vic (guest-star Bryan Callen), who abandoned his family three years ago, has changed his ways and wants to be part of Peter's life again. In the wake of this monumental news, Chandler must decide how this will impact his relationship with Paris (guest-star Shannon Kenny) and Peter. Meanwhile, Ruthie feels that Peter is pushing her away during this chaotic time and Reverend Camden finds a philanthropic way for the community and his family to embrace Vic.

Eric feels he must intervene when Martin, who recently moved in with the Camdens, is recruited by a professional baseball team, the Miami Gators and considers dropping out of school. Meanwhile, Ruthie enlists Lucy's help to convince their mom that she should be allowed to attend a couples party with Peter. Finally, Chandler's mother (guest star Concetta Tomei) pays him an unwelcome visit when he is named executor of his father's estate. A rift happens between Lucy and Annie where an angered Lucy considers moving. Lastly, Cecilia teaches Sam and David on how to ride a bike.

On a temporary leave from military duty in Iraq, Martin's father (guest-star Costas Mandylor) pays the Camdens a visit to help his son decide whether to forgo college for a career in professional baseball. However, the visit turns sour when Martin catches his father kissing Roxanne. Meanwhile, Chandler and Paris (guest-star Shannon Kenny) reevaluate their relationship in the wake of her ex-husband's return, and Roxanne comes to blows with Martin's aunt (guest-star Keri Lynn Pratt) over their differing views on the war in Iraq. Lastly, Vic tries to join the Marines and talks to a supervisor over the matter.

Annie's half-sister Lily (guest-star Michelle Phillips "Knots Landing" and "The Mamas and The Papas") shows up on her doorstep to discuss an important family matter after Annie refused to contact her. Eric tries to figure out why Annie won't contact Lily. Meanwhile, Cecilia sets Martin's friend Mac (guest-star Kyle Searles) up with a girl from school, but he doesn't want to go out with her because of something embarrassing that happened 10 years ago; Ruthie and Peter put a bad spin on a school project that lands them in trouble when they create a newspaper featuring false and derogatory stories about two former U.S. presidents. Lastly, Roxanne turns to Chandler when she finds herself faced with a moral dilemma as she is keeping a secret from Kevin regarding Det. Michaels. Det Michaels is promoted to Captain.

Matt (guest-star Barry Watson) returns to Glenoak to celebrate a special anniversary with Ruthie and tries desperately to avoid seeing the rest of the family. However, when Lucy discovers the secret, she, Eric and Annie go crazy trying to figure out why he's in town. Meanwhile, Martin shares something special with Cecilia. Also, Annie lets it slip to nurse Kelly (guest-star Debi Mazar) that Matt and Sarah are married. Lastly, Vic (guest-star Bryan Callen) invites Paris (guest-star Shannon Kenny) to spend a special evening with him, but she doesn't want to go because she thinks he might propose.

Annie's half-sister Lilly (guest-star Michelle Phillips, "Knots Landing" and musical group "The Mamas and The Papas") is getting married and wants their ailing father to walk her down the isle but Annie worries that the strain might be too much for him. Meanwhile, Fred (guest-star Al Ruscio) and Mrs. Bink (guest star Eileen Brennan) attend premarital counseling with Chandler, but Fred's mother (guest-star Carol Arthur) tries to put a stop to the wedding because she thinks Mrs. Bink is a gold digger. Lastly, Jimmy (guest-star Glen Poehlman) and Pat (guest-star Pam Rawuka), two mentally challenged people, decide to get married after just one date and ask Chandler to perform the ceremony, but Jimmy's parents (guest-stars Dick Van Patten and Patricia Van Patten) try to put a stop to it.

The Camdens, especially Lucy and Ruthie, grow concerned that an unusually joyful Annie isn't dealing with her true emotions following the death of her father Charles, but the happiness proves to be infectious as it soon spreads through the family and all over town. Meanwhile, Eric tries to convince an unhappy Chandler that he should consider adoption, which leads to a meeting with a lawyer (guest-star Randy Spelling). At the same time Chandler is approached by a mysterious young girl who gives him a cryptic message before she disappears.

Prospective homeowners Lucy and Kevin are ready for a fight to the finish when they learn that Chandler and his soon-to-be-adopted son Jeffrey (guest star James Henrie) are their rivals in a bidding war on a house. However, the conflict sparks an idea with Eric and Annie who decide to use their savings to buy their house from the church. Meanwhile, Ruthie is upset with Martin because she thinks he will get the garage apartment instead of her when Lucy and Kevin move out, and Peter suspects that his dad, Vic (guest star Bryan Callen), might be having an affair.

Lucy and Kevin celebrate their one-year wedding anniversary and contemplate whether they're ready to start a family, but things don't go off smoothly as Lucy refuses to drink champagne with Kevin during their anniversary dinner. Cecilia and Martin realize that their relationship may face a rocky future if Cecilia goes away to college. Chandler's foster son asks him to rid their house of all alcoholic beverages. Peter lies to Ruthie about his plans for the evening when she asks him to help her baby-sit the twins. With that, Peter goes missing, but concern turns to disappointment when Eric and Vic (guest-star Bryan Callen) find him drinking alcohol with his friends at the park. Lastly, a new couple in town calls on Eric and Annie for help...on decorating their new home.

Lucy finds her husband Kevin and his partner Roxanne in a compromising position while on an undercover police assignment, Cecilia and Martin's relationship hits another bump in the road when their after-school commitments get in the way of one-on-one time, and Chandler may have bitten off more than he can chew as a new parent. Meanwhile, Ruthie and Peter, who get lost during a school field trip, cross paths with "Lost Boys" Nicodemus and Jacob, who not only take care of them until Reverend Camden arrives, but also share the heartbreaking story of their struggle to stay alive during the civil war in Sudan. Ruthie and her boyfriend Peter get stranded after accidentally missing their bus during a school field trip. However, fate intervenes when the youngsters cross paths with "Lost Boys" Nicodemus and Jacob, who not only take care of them until Reverend Camden arrives, but also share the heartbreaking story of their struggle to stay alive.

It's Camden chaos all around when Matt (guest-star Barry Watson), who is having problems in his marriage to Sarah (guest-star Sarah Danielle Madison), returns to Glenoak for a visit and runs into his ex-girlfriend Heather (guest-star Andrea Ferrell) on his flight to Glen Oak. Simon (guest-star David Gallagher) unexpectedly announces he's coming home for the summer. Also, Lucy sets out to discover why Roxanne is suddenly too busy to hang out with her as she's convinced that Roxanne is secretly trying to become a detective behind Kevin's back. Ruthie keeps a secret about a fellow student from her parents. Lastly, Martin learns that his baseball teammates think he's having sex with Cecilia

The Camden chaos continues with Matt (guest star Barry Watson), who is trying to salvage his marriage, questioning whether he still has feelings for his ex-girlfriend Heather (guest star Andrea Ferrell); Simon's (guest star David Gallagher) return to Glenoak creates conflicted feelings for his ex-girlfriend Cecilia, who is torn between her feelings for Simon and her current boyfriend Martin; Ruthie's foreign exchange student friend Maria (guest star Samantha Sandoval), appears to be making the moves on Ruthie's boyfriend Peter; and grandparents-to-be Eric and Annie hop a plane for New York, despite Mary's (Jessica Biel, who does not appear in the episode) repeated pleas for her family to stay away during labor.