On one night in Sheffield, lives are changed for ever as a mysterious woman, unable to remember her own name, falls from the night sky.

Still reeling from their first encounter, can the Doctor and her new friends stay alive long enough in a hostile alien environment to solve the mystery of Desolation? And just who are Angstrom and Epzo?

Montgomery, Alabama. 1955. The Doctor and her friends find themselves in the Deep South of America. As they encounter a seamstress by the name of Rosa Parks, they begin to wonder whether someone is attempting to change history.

'Something's happening with the spiders in this city.' The Doctor, Yaz, Graham and Ryan find their way back to Yorkshire - and Yaz's family - only to find something is stirring amidst the eight-legged arachnid population of Sheffield.

Injured and stranded in the wilds of a far-flung galaxy, the Doctor, Yaz, Graham and Ryan must band together with a group of strangers to survive against one of the universe's most deadly - and unusual - creatures.

India, 1947. The Doctor and her friends arrive in the Punjab, as India is being torn apart. While Yaz attempts to discover her grandmother's hidden history, the Doctor discovers demons haunting the land. Who are they, and what do they want?

A mysterious message arrives in a package addressed to the Doctor, leading her, Graham, Yaz and Ryan to investigate the warehouse moon orbiting Kandoka, and the home of the galaxy's largest retailer, Kerblam.

In 17th-century Lancashire, the Doctor, Yaz, Ryan and Graham become embroiled in a witch trial and the arrival of King James I.

On the edge of a Norwegian fjord in the present day, the Doctor, Ryan, Graham and Yaz discover a boarded-up cottage and a girl named Hanne in need of their help. What has happened here? What monster lurks in the woods around the cottage - and beyond?

On the planet of Ranskoor Av Kolos, a battlefield, a conflict-scarred survivor, and a deadly reckoning await the Doctor, Ryan, Yaz and Graham.