Flynn Carsen, a professional student with 22 academic degrees. When he is booted out of his archeological dig, Flynn is hired by the Metropolitan Public Library as The Librarian. What Flynn does not realize is that the library has existed for centuries and protects a range of historical and often magical items in a secret section of the library, including The Ark of the Covenant, Pandora's box, and Excalibur. When part of the Spear of Destiny is stolen from the library, Flynn must recover it with the help of Nicole Noone, a beautiful marshal arts expert.

Flynn Carsen, a year after his first mission as the Librarian, has been on many more death-defying missions to protect the world from evildoers, including a trip to Utah to recover a mystical crystal skull. Upon his return to the Library, the audience is introduced to more mythic artifacts stored there: The Head of Medusa, the Trident of Poseidon, the Shroud of Turin, and the Pipes of Pan. He has moved out of his mother's house into his own apartment, but still feels held back by Judson, his supervisor, who tells him that "sometimes you have to give up what you want for the greater good" in order to go from being a "good librarian" to a "great librarian".

Curse of the Judas Chalice finds Flynn suffering from a series of strange dreams which lead him to New Orleans, where he finds himself in the midst of uncovering a conspiracy that involves the notorious vampire Prince Vlad Dracul. Once again, Flynn must overcome his fears and protect one of the world's most sacred artifacts, the Judas Chalice, or face the consequences of it falling into the wrong hands.