It's Adam's first day as clinical lead. His first job is to show eight new F2s around the ED, which backfires when they are not all what they seem to be. When Adam is called to an emergency at a shopping centre, he chooses new F2 Heather to accompany him. The owner of the centre has set a bomb inside, which explodes, trapping Adam, Heather, Jeff, Polly and a group of homeless people inside. Meanwhile Yuki, May and Lenny are ordered out of resus by now-Trust Doctor Ruth Winters and Curtis' memorial tree is planted.

In the conclusion to the first episode, Adam and the gang get out of the shopping center however he goes back for Heather. He finds her and they set out to get out. Jeff and Lee (the security guard) go in and find them but the roof collapses on Adam, Heather, Lee and the patient. They manage to find the lifts and escape but the lift starts to fall. Adam, the patient and Lee manage to climb up to the exit but Heather, being very slow, is petrified and she screams for Adam to save her. As they both try desperately to reach out for each other, the flaming lift collapses and hits Heather, crushing her and sending her falling to her death as the lift explodes in a fireball that ricochets up the passage, nearly burning Adam. Meanwhile Jessica is frantic and worried about Adam and chaos reigns in the department when the casualties flood in. Adam feels that he has let himself down.

May, Yuki and Lenny start their first shift after Heather's death. Adam patches them off with Zoe and she takes Lenny, Jeff and Polly take Yuki and Ruth takes May. They eventually are asked to sit out. At the end of the day the three go to a counselling session with Ben Harding. He describes May as the Scarecrow (no brain), Lenny as the Tin Man (no heart) and Yuki as the Lion (no courage) from The Wizard of Oz. Meanwhile Zoe is neglecting her work to take mysterious calls about Nick Jordan and an old face returns.

The episode recaps the three weeks before Jordan goes into a coma. These include meeting a penniless Italian hotel maid and a game of cat and mouse on Zoe's part between Nick, his neurologist Dr Frances Lively and the infamous Professor Walter McFey, who Zoe persuades to operate on Nick, with a operation that could either potentially save his life, or leave him with severe disabilities if he pulls through. How far will she go to save her patient?

Ruth attempts to keep her relationship with Jay secret while trying to impress her boss, Consultant Neurologist Sarah Evans. Nick's condition deteriorates and Zoe lies to Frances about Nick consenting to the operation. Ruth finally goes public with Jay but later worries that she might be pregnant.

Ruth discovers that she is indeed pregnant, while Sarah Evans invites her to a surgeons' dinner. Jeff has a new paramedic partner, who he takes a dislike to and reports him to Dixie after catching him looking through a patient's belongings. Zoe yet again abandons her work as Nick is discharged into her care - but he gets in a taxi and goes home alone. Adam is angry with Zoe but she stuns the department by announcing that Nick is recovering after having had the operation.

Ruth goes to the surgeons' dinner with Sarah Evans but leaves Jay behind - Jay turns up and is thrown out, but Ruth collapses, haemorrhaging, due to having taken an abortion pill. Charlie visits Nick, who seems to have given up on life. Meanwhile, the F2s are trapped in resus with Jessica by an angry relative of a dying patient and must perform a difficult procedure while Adam is forced to watch from outside.

Ruth is brought into the ED after collapsing and then spends 3 hours in theatre with the gynaecology surgeons. Sarah Evans tells her that she needs doctors without any distractions on her team, and Ruth coldly pushes Jay away. Adam assigns Lenny, May and Yuki a case of a man who alleges that he can see elves. Yuki manages to diagnose his condition and is asked out on a date by May. Zoe finds that her new boyfriend is a 15 year old schoolboy, who steals her memory stick so that she is forced to see him again.

Zoe is forced to tell Adam and Henry about her missing memory stick and she is given until 4pm to retrieve it. At the last minute, Jordan steps into help Zoe. Polly and Alistair's relationship goes way beyond normal, when Alistair breaks into Polly's flat. Polly is horrified to see him, as all she wanted was a friendship, and she then calls the police.

To the delight of the hospital staff in the Emergency Department (ED), Jordan returns but, this time, in an unfamiliar administrative role. Jordan is disappointed not to be on the front line but sparks are soon flying when he steps in to assist Lenny in treating bonfire-night casualties. A major incident at a pub, involving a box of fireworks, ensures that it's going to be a long, emotional night in ED. One victim is a young anorexic girl, Fran. To her mother Jenny's consternation, she refuses to have a saline drip in case she puts on weight. Can the medical staff persuade her to accept treatment and talk to her mother about her problems? Meanwhile, it's Jeff's first shift as a solo rapid responder but disaster strikes when, on his first call, he is attacked from behind and left bleeding. The blow to the head also leaves him disorientated and unable to remember exactly who attacked him. For some reason, the name coming to his mind is Alistair.Deeply concerned, Polly decides to pay a v

Injured pet shop proprietor Malcolm faces the loss of his home and business and the F2s are given their first patient to treat alone, as the medical drama continues. During a heated discussion with his landlord, Malcolm slips while holding a fish tank and suffers severe lacerations. While Malcolm is in casualty, the landlord is forced to reveal that he wants to build a car park on the site of the pet shop and Malcolm and his wife, Brenda, face losing their home and livelihood. Yuki needs to use all his diplomacy skills when, at the end of his tether, Malcolm decides to take matters into his own hands. Later, Yuki, May and Lenny are thrilled when Adam gives them their own patient to treat - Ruth's friend, Amir, who has a history of heart problems. Ignoring advice from Jordan, however, the F2s decide to follow their own course of treatment. Things go from bad to worse when the patient then goes missing. The F2s conceal their panic but are individually distraught. Elsewhere, paramedic Pol

Tensions are running high in the emergency department as the F2s nervously await an important decision and Ruth struggles to impress Dr Sarah Evans by treating a patient alone. With the department at full stretch treating casualties from a major fire and a car accident victim with cerebral palsy, the F2s bicker through their shift as they anxiously await the fall-out from their treatment of Amir. Adam warns them that they must continue to work as part of a team but Ruth, in particular, is reluctant to work with them and the young medics are uneasy. Could this be the end of their short careers as doctors? Keen to impress neurological expert Dr Sarah Evans, Ruth refuses to ask for advice about the cerebral palsy patient, preferring to struggle on alone. But when the patient's condition worsens, the vastly experienced Jordan steps in to help. Will Ruth be honest about the situation? And where exactly does her future at the hospital lie? Meanwhile, massage parlour workers Bree and Joy are

The F2s are thrilled when the dean announces a Junior Academic Fellowship Award which will see one of them win a role in the ED with a lucrative salary. However, Adam warns them they must still work together as a team and not be tempted by individual success. May, in particular, is desperate to win the award. However, mentored by the impatient Ruth, things don't get off to a good start. When a bank robbery goes horribly wrong, injured bank manager, Gal, is brought into casualty with a gun-shot wound. But Gal isn't quite the hero he first appears and his obsessive behaviour brings back some disturbing memories for Polly. When Gal starts waving a gun around the ED, Polly leaps into action, putting everyone at risk. It's time for the young paramedic to relive and confront exactly what happened with Alistair in order to get her life, and career, back in order. Meanwhile, Jordan is keen to return to a more hands-on role in the ED. However, despite the department being at full stretch, Adam

Ruth is horrified when Jonathan turns up in the Emergency Department (ED) looking for her help – much to Jay's surprise, who didn't even realise she had a brother. Jonathan swears to Ruth that he has turned over a new leaf but she sees the track marks in his arms and refuses to believe that he's changed. Later, a group of hard-drinking homeless men cause havoc in ED when they start stealing bottles of alcohol-based hand sanitiser from the wards and take it back to an unsafe hospital annexe to enjoy in private. Tragedy strikes when young security guard Mick, desperate to win Ruth's approval, confronts the homeless men on his own, but Jonathan, who has seen the commotion, is quick to get help. Will his part in the events convince Ruth that he's changed and that she can help him make a fresh start? Meanwhile, Jessica and Adam's wedding arrangements continue apace but Adam struggles to maintain his composure when interference comes from an unwelcome source...

Competition for the fellowship hots up and the pressure is intense for the F2s, as the medical drama continues. Lagging behind the others, Yuki desperately needs to prove himself and, when a work outing goes disastrously wrong, he gets exactly the chance he needs. Yuki is failing fast in the race for the fellowship and his mentor, Zoe, blames it on his lovesick glances for May. She challenges him to ask her out for a drink. However, a coach-load of crash victims proves a serious distraction. Jim, a young man who sabotaged the bus with his best mate, Pete, for a laugh, is horrified when Becky – a girl he fancies – dies in the crash. He confesses all to Yuki, who advises him to do the right thing, but puts himself in danger in the process. Meanwhile, Jordan is desperate to return to the resus room from his exile in admin. Outside the hospital, he is recognised by a man who collapses in front of him. Once revived, it's clear the man has no idea who he is. Unable to get hold of Adam, who i

Ruth faces a festive family crisis, Lenny considers the prospect of unwanted early Christmas leave and Zoe continues to enjoy a bit too much seasonal "spirit" in this year's festive offering of the medical drama. As the competition for the fellowship continues, May is frustrated by always being regarded the least-promising of the F2s and plays a trick on Lenny which has far-reaching consequences. Acting on May's misinformation, Lenny mistakenly tells two sisters that their father, Barry, has died. He is severely reprimanded by a stressed and furious Adam and it looks as if Lenny's Christmas leave may be lasting a little longer than he would like. Ruth, meanwhile, is looking forward to celebrating Christmas with a long-lost member of her family when she notices an heirloom has gone missing from her flat. As she's plunged into a world of stolen phones, heroin overdoses and male prostitution, Ruth realises that she's likely to face Christmas alone. Will this mean she's ready to accept the

It's Christmas party fever in the Emergency Department (ED) on Boxing Day as Noel heads to the celebrations at his father, David's, old people's home, and there's also the Dean's annual bash for the staff to look forward to. After a tough night in the ED, Zoe offers Noel a lift to his father's party. Noel is devastated when he doesn't recognise him but seems very close to another visitor, Jimmy. He's further worried by the fact that his father and several other residents seem ill. He begs Zoe to help his father. The F2s are on their way to help Noel's Charity Christmas visit but are suddenly called into action when they come across a car crash. Working together, they manage to stabilise their patients and get them to the ED. They are hailed as heroes by Adam in front of their colleagues and superiors at the Dean's Christmas party later that evening. The Dean, Eddie, proudly boasts to Henry that May is his daughter but she then tells him that she wants to make it on her own. Henry blurt

Feature-length episode. The big day dawns for Adam and Jessica as they prepare for their wedding but Adam is feeling rather worse for wear, as the medical drama continues. Adam emerges from the on-call room dressed as superman, following a heavy night. He walks past Henry and Zoe with as much dignity as possible but knows Jessica is going to be furious. As he prepares to leave the chaotic ED, he promises Jessica he won't be late – only to walk straight into the path of a patient, who collapses. At their country house venue, Jessica waits impatiently for Adam as the guests start to arrive. Charlie races Adam, who manages to wangle a police escort. As the service gets under way, Adam and Jessica get the giggles. But, before they are officially named man and wife, Tess interrupts – there's been a major road accident. Much to Jessica and the registrar's disgust, Adam returns to the hospital. Back at the hospital, Yuki and May are working well in the crisis unit, but Yuki is struggling to f

The staff try to carry on as normal after the car accident, as the medical drama continues. Meanwhile, Lenny's "brother" turns up at Holby City ready to execute a long-standing plan which could have huge implications for Lenny. Lenny is delighted when long-lost friend Davey turns up at the hospital but he's less than pleased when he hears why he is back. Davey wants to carry out a plan that the two boys hatched when they were younger – to torch the children's home they both grew up in. To Lenny's horror, Davey goes through with his plan, unaware that there is someone else inside the building. Polly's career is on the line when the hearing takes place into her conduct around Alistair's death. The young paramedic is troubled when Alistair's friend, Abe, turns up to tell her that he wants her to know what it's like to lose something she cares about. She is even more concerned when Jeff's attempt to defend her turns out to be less than helpful. Charlie's son, Louis, is back in his father's

Following the traumatic events of the New Year, Jessica takes a look back at her life, loves and career at Holby. It's 1998 and Jessica is a young nurse, casually flirting with Sean and enjoying wild nights out with best mate Linda. When Linda leaves to travel around America she gives Jessica a pebble saying that if Jessica ever finds herself in trouble it will be her lucky charm. A few years later, Jessica and Sean get married. Sean is keen for Jessica to take elocution lessons so that she sounds like a successful surgeon's wife and Jessica is keen to return to work after the birth of Amelia – much to Sean's distaste. It appears that married life isn't a bed of roses for the couple. When Amelia is older, Sean and Jessica's marriage is on shaky ground when, at a low ebb, Jessica meets Adam in a pub, goes home with him and is moved by their strong connection. Back in the present day, Linda checks up on her old friend and it's time for Adam to find out how his confession has been receive

While Adam keeps waiting by Jessica's bedside, life goes on in the Emergency Department with exams approaching for the increasingly stressed F2s. When May fails to impress Ruth and makes a clinical error, Ruth unleashes a barrage of anger on her mentee. Feeling low and worried May retaliates, resulting in a furious Ruth sending her home. Lenny can't believe his luck – with May having such a rough time and Yuki unexpectedly missing, it looks like the Fellowship is in the bag. Still raw from her confession about the abortion, Ruth has a heated conversation about May with Jay, during which he tells Ruth that she should try and be more empathetic. Brought up short by this, Ruth pays May a visit at home, where she is horrified to see May slumped in a chair, with an open bottle of wine and some pills nearby. The Ambulance Trust has made its decision in Polly's tribunal about Alistair's death, but she doesn't care either way; too scarred by events, she is determined to resign anyway. Jeff and

It's a day of high tension as the young doctors try desperately to impress, with mixed fortunes, in the F2s' exam. May is given a pep talk by her father, Eddie, and is shocked when he hands her an envelope with the exam questions inside in order to help her along her way. And all the F2s are rattled when Jordan reveals that the exam will also include a day-long assessment, overseen by Henry. Yuki falters while treating Seb, a seriously ill teenager, but redeems himself when he comes up with a brilliant diagnosis. However, when he bravely tells a packed meeting that Seb told him he no longer wants to receive treatment, Henry orders him out of the room. Over-confident Lenny, meanwhile, is disappointed to be stuck in cubicles and, determined to impress, orders a series of tests for elderly patient Chick. However, he is distressed when the tests reveal something sinister and tries in vain to persuade his patient to accept treatment. May initially impresses Henry when surgeon Sarah Evans is

Adam and Jessica struggle to keep their personal and professional lives on track after the tragic events of the past few weeks. It's the week after Harry's funeral and Jessica is finding it increasingly difficult to live and work with Adam as he reminds her so much of everything she's lost. When Jessica's long-lost friend, Linda, turns up at the Emergency Department with an injured arm, she outlines a proposition to Jessica which gives the grieving mother some food for thought. Elderly patient Mrs Bullock, meanwhile, is brought into the ED distressed and disorientated by a disturbing vision of a clown. Could her condition have anything to do with the energy drinks she's been consuming? Dixie is delighted when her father, Arthur, turns up out of the blue but saddened when he tells her some unexpected news. When Arthur sees Dixie and Jeff sharing a joke together and tells Dixie he's glad she has a supportive boyfriend, something stops her from correcting his mistake. Dog-lover Dom is sur

(Crossover with Holby City; part two is S12E19: Downstairs, Upstairs (2)) Charlie's chest pains are worsening, and his stress levels increase further when he gets a phone call from the police and Louis - Shona has broken into his house. He angers Louis by refusing to press charges against Shona, vowing to deal with her himself. Later he is forced to chase Shona around Holby and finds her drunk and high, slumped in a graveyard.He starts to drive her home, but a combination of the day's events and worsening pains causes Charlie to cough up blood. Shona rushes for help and Charlie is whisked into the ED, where the team stabilise him. The gang rally round as Charlie is taken upstairs to Elliot and the Holby team.Adam insists he's fine to work, but when he upsets a patient Jordan orders him to attend a counselling session before he returns. Annoyed, Adam begrudgingly agrees but, when he is later drafted in for a five-a-side football match, he takes his frustration out on a vicious player

There are two new faces in the Emergency Department this week, as the medical drama continues. Robert Boulter arrives as a handsome young doctor who ruffles May's feathers; and Hotel Babylon's Raymond Coultard plays Dr Matt Strong, who has his heart set on Zoe. Meanwhile, a bereavement counsellor gets more than he bargained for from Adam. May is distracted when a handsome stranger turns up in Holby on a motorbike but, when she sees him in cubicles later, she is her usual snooty self. When the stranger reveals himself as Dr Kieron Fletcher, a young research doctor who's hoping to apply for the fellowship, May is seriously unimpressed. Kieron turns out to be a more than capable colleague, but just what is sparking his unusual interest in Jordan? Relaxing after work with a glass of wine, Zoe contacts Jordan to bury the hatchet and offer her full support now that he's head of the ED. But a bottle later, Zoe is horrified to realise that she's left a stream of messages about their relations

When disaster hits a pleasure cruiser on a lake, Adam is forced to face his demons...but will he accept his own mortality?

Jordan finds himself driven to the middle of nowhere against his will...it seems that someone has something important to tell him.

Adam seems outwardly to be getting over Harry's death, but as the cracks start to show, Alice realises that he is bottling everything up. And when these pent up feelings are unleashed, Alice finds herself in an impossible situation...

There's a wedding and a betrayal...and one of the gang makes a fatal mistake in resus...

It's the day of a very important internal review at the ED, and Ruth finds herself in an impossible situation with one of her colleagues...will career ambitions ride roughshod over the truth?

A motorbike accident makes Jordan realise that he cares more than he realised about one of his staff. And Zoe receives an interesting offer ...

Adam's insensitivity with an elderly patient backfires...whilst elsewhere, a DNA test comes back with surprising results for all concerned.

As Adam's erratic behaviour spirals completely out of control, events take a nasty turn in an out-of-the-way farmhouse.

With the police closing in, and Adam fighting for survival...an old face returns to Holby...and maybe, just maybe, they hold the key to stopping the madness...

With Holby ED sent into lock-down, the F2s and Charlie fight for their lives as something deadly is unleashed...

Adam is forced to face the loss of his son, while Jordan discovers Jay could be in mortal danger.